F盒蛋白
Skp1型
卡林
癌变
泛素连接酶
生物
蛋白质水解
计算生物学
泛素
蛋白质-蛋白质相互作用
细胞生物学
泛素蛋白连接酶类
细胞分裂控制蛋白4
癌症
生物信息学
遗传学
生物化学
酶
基因
作者
Zhi-wei Wang,Pengda Liu,Hiroyuki Inuzuka,Wenyi Wei
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2014-03-24
卷期号:14 (4): 233-247
被引量:413
摘要
F-box proteins, which are the substrate-recognition subunits of SKP1-cullin 1-F-box protein (SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through ubiquitylation and subsequent degradation of target proteins. Dysregulation of F-box protein-mediated proteolysis leads to human malignancies. Notably, inhibitors that target F-box proteins have shown promising therapeutic potential, urging us to review the current understanding of how F-box proteins contribute to tumorigenesis. As the physiological functions for many of the 69 putative F-box proteins remain elusive, additional genetic and mechanistic studies will help to define the role of each F-box protein in tumorigenesis, thereby paving the road for the rational design of F-box protein-targeted anticancer therapies.
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