Studies on the relative binding affinities of chlorhexidine analogs to cationexchange surfaces

An in vitro model system was employed ot dtermine the relative binding affinities fo a series fo sixteen chlorhexidine analogs to acidic funcitonal groups similar to those which are abundan in the oral cavity. The chlorhexidine analogs displayd a range ofbindign affinities and were dispalced subsequent ot binding from caboxylate and phosphonate substituted resins, although not from sulphnate substituted resins, by divalent cations or by saliva‐like divalent cation‐rich solutions. The agent were not displaced from such surfaces by monovalent cations there appears to be no correlation between the relative binding affinities fo agents to anionic groups and their previously observed in vitro antiplaque potencies.