化学
三氟甲基化
重氮
氘
铜
三氟甲基
范围(计算机科学)
组合化学
氧化物
有机化学
计算机科学
量子力学
物理
程序设计语言
烷基
作者
Mingyou Hu,Qiqiang Xie,Xinjin Li,Chuanfa Ni,Jinbo Hu
标识
DOI:10.1002/cjoc.201600004
摘要
Abstract A copper‐mediated deuterotrifluoromethylation of α ?diazo esters under the promotion of deuterium oxide (D 2 O) has been developed for the synthesis of deuterium‐labeled trifluoromethyl compounds. This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.
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