磺胺吡啶
溃疡性结肠炎
髓过氧化物酶
结肠炎
医学
胃肠病学
炎症性肠病
肿瘤坏死因子α
牛磺胆酸
内科学
消炎药
炎症
胆汁酸
药理学
疾病
作者
Yang Yang,Jing He,Shuguang Yuan,Le Lv,Jingjing Wang,Chuanchuan Huo,Zongwei Zheng,Ziye Wang,Jing Li,Wenli Sun,Yongmin Zhang
标识
DOI:10.1016/j.biopha.2016.04.037
摘要
Taurocholate is a natural conjugated bile acid. The aim of this study was to evaluate the anti-inflammatory effect of taurocholate in TNBS-induced ulcerative colitis in mice. The colitis were induced by rectal administration of TNBS. After 24h, the experimental animals were treated with sulfasalazine (SASP, 500mg/kg/day) and taurocholate (20, 40 and 60mg/kg) for 7 consecutive days. The anti-inflammatory effects of taurocholate for colitis were assessed by body weight, colonic weight and length, macroscopic scores, and histopathological examinations. In addition, the colonic tissue levels of myeloperoxidase (MPO) activity, interleukin (IL)-1β, interferon (IFN-γ) and tumour necrosis factor-α (TNF-α) were also determined to assess the effect of taurocholate. Compared with the model group, treatment with taurocholate (20, 40 and 60mg/kg) significantly inhibited the body weight loss, improved colonic weight and length, and decreased macroscopic and histopathological scores. Furthermore, the activity accumulation of MPO and the colonic tissue levels of IL-1β, IFN-γ and TNF-α were also decreased by administration of taurocholate. All the findings of this study suggested that taurocholate has the anti-inflammatory effect in ulcerative colitis in mice and indicated it as a good candidate to treat inflammatory bowel disease.
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