内分泌系统
骨重建
医学
骨钙素
葡萄糖稳态
平衡
内分泌腺
生物信息学
内分泌学
激素
内科学
生物
糖尿病
胰岛素抵抗
碱性磷酸酶
酶
生物化学
作者
Anyonya R. Guntur,Clifford J. Rosen
摘要
Objective To review the recent evidence that has emerged supporting the role of bone as an endocrine organ. Methods This review will detail how bone has emerged as a bona fide endocrine “gland,” and with that, the potential therapeutic implications that could be realized for this hormone-secreting tissue by detailing the evidence in the literature supporting this view. Results The recent advances point to the skeleton as an endocrine organ that modulates glucose tolerance and testosterone production by secretion of the bone-specific protein osteocalcin. Conclusions Bone has classically been viewed as an inert structure that is necessary for mobility, calcium homeostasis, and maintenance of the hematopoietic niche. Recent advances in bone biology using complex genetic manipulations in mice have highlighted the importance of bone not only as a structural scaffold to support the human body, but also as a regulator of a number of metabolic processes that are independent of mineral metabolism. (Endocr Pract. 2012;18:758-762)
科研通智能强力驱动
Strongly Powered by AbleSci AI