医学
生活质量(医疗保健)
判别效度
皮肤科生活质量指数
皮肤病科
公式-5D
收敛有效性
内容有效性
患者报告的结果
疾病
表面有效性
心理测量学
银屑病
健康相关生活质量
内科学
临床心理学
护理部
内部一致性
作者
Deshan F. Sebaratnam,Anna Marie Hanna,Shien-Ning Chee,John W. Frew,Supriya S. Venugopal,Benjamin Daniel,Linda K. Martin,Lesley Rhodes,Jeremy Tan,Charles Qian Wang,Belinda Welsh,Tamar Nijsten,Dédée F. Murrell
出处
期刊:JAMA Dermatology
[American Medical Association]
日期:2013-10-01
卷期号:149 (10): 1186-1186
被引量:62
标识
DOI:10.1001/jamadermatol.2013.4972
摘要
Importance
Quality-of-life (QOL) evaluation is an increasingly important outcome measure in dermatology, with disease-specific QOL instruments being the most sensitive to changes in disease status. Objective
To develop a QOL instrument specific to autoimmune bullous disease (AIBD). Design
A comprehensive item generation process was used to build a 45-item pilot Autoimmune Bullous Disease Quality of Life (ABQOL) questionnaire, distributed to 70 patients with AIBD. Experts in bullous disease refined the pilot ABQOL before factor analysis was performed to yield the final ABQOL questionnaire of 17 questions. We evaluated validity and reliability across a range of indices. Setting
Australian dermatology outpatient clinics and private dermatology practices. Patients and Exposure
Patients with a histological diagnosis of AIBD. Main Outcomes and Measures
The development of an AIBD-specific QOL instrument. Results
Face and content validity were established through the comprehensive patient interview process and expert review. In terms of convergent validity, the ABQOL was found to have a moderate correlation with scores on the Dermatology Life Quality Index (R = 0.63) and the General Health subscale of the 36-Item Short Form Health Survey (R = 0.69;P = .009) and low correlation with the Pemphigus Disease Area Index (R = 0.42) and Autoimmune Bullous Disease Skin Disorder Intensity Score (R = 0.48). In terms of discriminant validity, the ABQOL was found to be more sensitive than the Dermatology Life Quality Index (P = .02). The ABQOL was also found to be a reliable instrument evaluated by internal consistency (Cronbach α coefficient, 0.84) and test-retest reliability (mean percentage variation, 0.92). Conclusions and Relevance
The ABQOL has been shown to be a valid and reliable instrument that may serve as an end point in clinical trials. Future work should include incorporating patient weighting on questions to further increase content validity and translation of the measure to other languages. Clinical Trial Registration
anzctr.org.au Identifier:ACTRN12612000750886
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