神经科学
背景(考古学)
医学
步态
病理生理学
现象
疾病
机制(生物学)
脑干
物理医学与康复
心理学
病理
生物
古生物学
哲学
物理
认识论
量子力学
作者
James M. Shine,Sharon L. Naismith,Simon J.G. Lewis
标识
DOI:10.1016/j.jocn.2011.02.007
摘要
Freezing of gait is a paroxysmal phenomenon most commonly found in patients with advanced Parkinson's Disease. The pathophysiological mechanisms underlying this behaviour remain uncertain despite a well-characterised phenotype. Freezing behaviour extends beyond gait to affecting speech and upper limb function, suggesting that there is likely to be a universal mechanism underlying the phenomenon. This paper identifies the essential features required for a comprehensive model of freezing and evaluates a number of hypotheses that seek to explain the phenomenon. It appears likely that the pathophysiology of freezing involves context-dependant dysfunction across multiple levels of the neurological system, including cortical, subcortical and brainstem regions.
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