六烯酸
医学
花生四烯酸
安慰剂
随机对照试验
不利影响
临床终点
儿科
生理学
多不饱和脂肪酸
内科学
脂肪酸
生物化学
生物
替代医学
病理
酶
作者
Christine Henriksen,Kristin Haugholt,Magnus Lindgren,Anne Karin Aurvåg,Arild Rønnestad,Morten Grønn,Rønnaug Solberg,Atle Møen,Britt Nakstad,Rolf K. Berge,Lars Smith,Per Ole Iversen,Christian A. Drevon
出处
期刊:Pediatrics
[American Academy of Pediatrics]
日期:2008-06-01
卷期号:121 (6): 1137-1145
被引量:216
标识
DOI:10.1542/peds.2007-1511
摘要
OBJECTIVE. The objective of our study was to evaluate the effect of supplementation with docosahexaenoic acid and arachidonic acid for human milk-fed preterm infants. The primary end point was cognitive development at 6 months of age. METHODS. The study was a randomized, double-blind, placebo-controlled study among 141 infants with birth weights of <1500 g. The intervention with 32 mg of docosahexaenoic acid and 31 mg of arachidonic acid per 100 mL of human milk started 1 week after birth and lasted until discharge from the hospital (on average, 9 weeks). Cognitive development was evaluated at 6 months of age by using the Ages and Stages Questionnaire and event-related potentials, a measure of brain correlates related to recognition memory. RESULTS. There was no difference in adverse events or growth between the 2 groups. At the 6-month follow-up evaluation, the intervention group performed better on the problem-solving subscore, compared with the control group (53.4 vs 49.5 points). There was also a nonsignificant higher total score (221 vs 215 points). The event-related potential data revealed that infants in the intervention group had significantly lower responses after the standard image, compared with the control group (8.6 vs 13.2). There was no difference in responses to novel images. CONCLUSIONS. Supplementation with docosahexaenoic acid and arachidonic acid for very preterm infants fed human milk in the early neonatal period was associated with better recognition memory and higher problem-solving scores at 6 months.
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