自噬
泡沫电池
生物
PI3K/AKT/mTOR通路
细胞生物学
巨噬细胞
磷酸酶
癌症研究
信号转导
细胞凋亡
生物化学
磷酸化
体外
作者
Anna Brichkina,Dmitry V. Bulavin
出处
期刊:Autophagy
[Informa]
日期:2012-10-16
卷期号:8 (10): 1545-1547
被引量:25
摘要
Atherosclerosis commonly causes coronary and cerebrovascular diseases, which are major morbidities worldwide. Controlling these conditions remains a challenge owing to an incomplete understanding of underlying molecular mechanisms. We have recently shown that PPM1D/WIP1 phosphatase plays a crucial role in regulating atherosclerosis in mice. Deletion of Ppm1d results in the suppression of lipid droplet accumulation in macrophages, which prevents the formation of foam cells, and ultimately the development of atherosclerotic plaques. This process is controlled by the ATM-MTOR pathway and depends on the activation of selective autophagy to regulate cholesterol efflux from macrophage foam cells. Our data suggest that modulating autophagy through the PPM1D-ATM-MTOR pathway may be beneficial at both early and advanced stages of atherosclerosis.
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