纳米载体
药物输送
叶酸受体
药品
靶向给药
生物相容性
药理学
纳米医学
纳米技术
癌症
癌症治疗
医学
癌细胞
化学
纳米颗粒
材料科学
内科学
有机化学
作者
Pedram Ebrahimnejad,Arezoo Sodagar Taleghani,Kofi Asare-Addo,Ali Nokhodchi
标识
DOI:10.1016/j.drudis.2021.11.011
摘要
The uncontrolled release of drugs in conventional drug delivery systems has led to the introduction of new nanotechnology-based drug delivery systems and the use of targeted nanocarriers for cancer treatment. These targeted nanocarriers, which consist of intelligent nanoparticles modified with targeting ligands, can deliver drugs to specified locations at the right time and reduce drug doses to prevent side effects. Folate is a suitable targeting ligand for folate receptors overexpressed on cancer cells and has shown promising results in the diagnosis and treatment of cancer. In this review, we highlight the latest developments on the use of folate-conjugated nanoparticles in cancer diagnosis and treatment. Moreover, the toxicity, biocompatibility and efficacy of these nanocarriers are discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI