地方政府
磁刺激
背外侧前额叶皮质
刺激
精神分裂症(面向对象编程)
脑电图
心理学
前额叶皮质
阳性与阴性症状量表
随机对照试验
医学
麻醉
神经科学
听力学
内科学
精神科
精神病
认知
作者
Zhilin Pan,Dongsheng Xiong,Huisi Xiao,Jiahui Li,Yuanyuan Huang,Jing Zhou,Jun Chen,Xiaobo Li,Yuping Ning,Fengchun Wu,Kai Wu
标识
DOI:10.1016/j.psychres.2021.113866
摘要
• 10Hz rTMS on left DLPFC as an adjunct treatment in patients with chronic schizophrenia. • A double-blind, randomized and sham-controlled trial. • 10 Hz rTMS stimulation improved positive symptoms in the active group. • The change of the duration of class D in EEG microstates was significantly different between the active and sham groups. The objective of this study was to investigate the effects of 10 Hz repetitive transcranial magnetic stimulation (rTMS) in patients with schizophrenia using EEG microstates. Thirty-eight patients with chronic schizophrenia were included in a double-blind, randomized and sham-controlled trial (19 participants in the active group and 19 participants in the sham group) and received 10 Hz active or sham rTMS stimulation to the left dorsolateral prefrontal cortex (left DLPFC) 5 days per week over for 4 weeks. Four classical microstate classes (i.e., classes A, B, C and D) were identified by clustering, and the parameters (i.e., duration, occurrence and contribution) of each class were computed. Our results showed that (1) after stimulation, the positive and negative syndrome scale (PANSS) positive scores decreased significantly in the active group; (2) the duration of the microstate of class C derived from EEG data decreased significantly in the active group; and (3) the change of the duration of class D in the active group was significantly higher than that in the sham group. Our findings demonstrated that 10 Hz active rTMS stimulation was beneficial to improving the positive symptoms of patients with chronic schizophrenia, and the EEG microstate could be an effective indicator of symptom improvements.
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