免疫原性
单克隆抗体
抗体
药效学
结合
药代动力学
药品
细胞毒性T细胞
化学
病毒学
抗体-药物偶联物
药理学
医学
免疫学
抗原
体外
生物化学
数学
数学分析
作者
Md. Mahbub Hasan,Mark Laws,Peiqin Jin,Khondaker Miraz Rahman
标识
DOI:10.1016/j.drudis.2021.09.015
摘要
In antibody-drug conjugates (ADCs), monoclonal antibodies (mAbs) act as carriers for a cytotoxic payload providing the therapy with targeted action against cells expressing a target cell surface antigen. An appropriate choice of mAb is crucial to developing a successful ADC for clinical development. However, problems such as immunogenicity, poor pharmacokinetic (PK) and pharmacodynamic (PD) profiles and variable drug-antibody ratios (DARs) plague ADCs. In this review, we detail recent mAb-based innovations and factors that should be considered to overcome these problems to achieve a new generation of more effective ADC therapeutics.
科研通智能强力驱动
Strongly Powered by AbleSci AI