甲氨蝶呤
微气泡
类风湿性关节炎
医学
体内
癌症研究
体外
药理学
化学
超声波
内科学
生物化学
生物
放射科
生物技术
作者
Zhuofei Zhao,Xiaona Lin,Lulu Zhang,Xia Liu,Qingwen Wang,Shaojun Yu,Guanghui Cui,Huali Cai,Yan Chen,Yongbin Li,Azhen Hu,Zhuxia Zhang,Jun Li,Hongjian Xie,Tingting Zheng,Xiaolong Liang,Xintao Shuai,Yun Chen,Desheng Sun
标识
DOI:10.1166/jbn.2021.3105
摘要
De novo designed lipidated methotrexate was synthesized and self-assembled into microbubbles for targeted rheumatoid arthritis theranostic treatment. Controlled lipidatedmethotrexate delivery was achieved by ultrasound-targetedmicrobubble destruction technique. Methotrexate was dissociated inflammatory microenvironment of synovial cavity, owing to representive low pH and enriched leucocyte esterase. We first manipulated methotrexate controlled release with RAW 264.7 cell line in vitro and further verified with rheumatoid arthritis rabbits in vivo . Results showed that lipidated methotrexate microbubbles precisely affected infection focus and significantly enhanced rheumatoid arthritis curative effect comparing with dissociative methotrexate. This study indicates that lipidated methotrexate microbubbles might be considered as a promising rheumatoid arthritis theranostics medicine.
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