生物相容性
铁
吸附
化学
聚合物
化学工程
高分子化学
肿胀 的
无定形固体
透明质酸
核化学
自愈水凝胶
无机化学
结晶学
有机化学
吸附
工程类
生物
遗传学
作者
Jiří Mrázek,J. Kohout,Tomáš Kmječ,Kristina Nešporová,Josef Chmelař,Lukáš Kubala,Vladimı́r Velebný
标识
DOI:10.1016/j.ijbiomac.2021.09.059
摘要
We present water-insoluble hyaluronan films crosslinked by trivalent iron developed as potential resorbable implants. The films were crosslinked by sorption of ferric salt into solid HA films in water/2-propanol bath. These heterogeneously crosslinked films (het-FeHA) remained tough and dimensionally stable when rehydrated in saline. In contrast, films prepared by drying the well-known homogeneous ferric hyaluronate gels (hom-FeHA) softened upon rehydration and expanded rapidly. Differences between hom-FeHA and het-FeHA result from polymer network topology (dominant inter- or intra-molecular crosslink, respectively). Moreover, Mössbauer spectroscopy of het-FeHA revealed diiron complexes, while iron in the hom-FeHA was present exclusively as γ-FeOOH nanoparticles or amorphous FeOOH. The biocompatibility tests of het-FeHA did not show any adverse effect and the sample disintegrated within one day when implanted in mice peritoneum. In conclusion, we developed implantable hyaluronan-based free-standing film with minimal swelling that can be resorbed quickly enough to avoid induction of foreign-body reaction.
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