Pseudomonas aeruginosa Biofilm: A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms (Adv. Sci. 12/2021)

In article number 2004369, Martin Empting and colleagues describe a new generation of dual-loaded nanoparticles enabling efficient eradication of Pseudomonas aeruginosa biofilms. The squalene-based nanocarrier facilitates co-delivery of a novel pathogenspecific Quorum Sensing Inhibitor (QSI) together with the standard-of-care antibiotic tobramycin. The QSI itself shows high anti-virulence efficacy, favorable DMPK and no overt safety pharmacology. When applied as the nanoparticle formulation the QSI potentiates biofilm eradication capabilities of tobramycin by at least 32-fold.