Enzyme‐free Electrochemical Detection of Hydrogen Peroxide Based on the Three‐Dimensional Flower‐like Cu‐based Metal Organic Frameworks and MXene Nanosheets†

Main observation and conclusion Cu‐based metal organic frameworks (MOFs) are regarded as promising sensing materials, which have abundant metal sites, large surface area and simple synthesis processes. In this work, a novel three‐dimensional flower‐like Cu‐MOF was synthesized, which was combined with ultra‐thin MXene nanosheets to construct a novel electrochemical sensor for H 2 O 2 . During the electrocatalytic reduction of H 2 O 2 , the catalytic activity of Cu‐MOF/MXene/GCE results in the ultra‐sensitive detection of H 2 O 2 owing to the structure properties of MOFs, the nature of Cu‐contained nanomaterials as well as the high electrical conductivity of MXene. The Cu‐MOF/MXene/GCE showed a wide linear range from 1 μmol/L to 6.12 mmol/L using chronoamperometry at the detection potential of –0.35 V, and the detection limit is estimated to be 0.35 μmol/L. The sensor also shows good anti‐interference due to the lower detection potential, specific catalysis of Cu‐MOF to H 2 O 2 , which promises the sensor good selectivity in complexed samples. Meanwhile, the electrochemical sensor is capable to detect H 2 O 2 in milk and serum samples with satisfactory recoveries. The ultra‐sensitivity, rapid detection, and easy operation of the proposed sensor present significant prospect for real‐time analysis and monitoring of H 2 O 2 in foods and biological samples.