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Aim To investigate the efficacy of enteral nutrient of short peptides through nasojejunal feeding tube on the pediatric digestive dysfunction and malnutritional status.Methods 30 patients were given with short peptide nutrient solution through the nasogastric feeding tube placed by endoscope and 32 patients were peripherally administered parenteral nutrition.Intestinal and pancreatic function was determined and nutritional serum protein and the complication were detected in both groups.Results In this study, The flatus time and the defecation time in catheter EN groups were significantly shorter than those in control PN group, P <0.05.The recovery time of urine amylase in catheter EN groups was significantly shorter than that in control PN groups, P<0.05.The prealbumin and retinol-binding protein levels at postoperative 3d in catheter EN groups were significantly higher than that in control PN groups, P <0.05. 5 cases (17%) of 30 children in catheter EN groups appeared complications including 3 cases of abdominal distension, 2 cases of vomiting. ConclusionThe study demonstrated that short peptide nutrient solutions given by endoscopic placement of nasojejunal feeding tube for critically ill children can significantly improve the intestinal and pancreatic function and malnutritional status.Moreover, it is safe and effective for home EN.