材料科学
纳米技术
制作
纳米探针
药物输送
纳米颗粒
基质(水族馆)
医学
海洋学
地质学
病理
替代医学
作者
Jinbin Pan,Yaqiong Wang,Haiyan Pan,Cai Zhang,Xiaogang Zhang,Yanyan Fu,Xuejun Zhang,Chunshui Yu,Shao‐Kai Sun,Xiu‐Ping Yan
标识
DOI:10.1002/adfm.201603440
摘要
Versatile bioinspired strategies are urgently needed to fabricate high-performance nanoprobes for biomedical application. Herein, a novel bioinspired technology of mimicking drug–substrate interaction is reported for the fabrication of high-performance nanoprobes. As a proof of concept, a multifunctional bovine serum albumin (BSA)-MnO2 nanoparticle-based nanoplatform is strategically engineered via mimicking the disinfection process of KMnO4 in an extremely facile way. The prepared BSA-MnO2 nanoparticles possess sub-10 nm and uniform size, excellent colloidal stability, and impressive T1 relaxivity of 7.9 mm−1 s−1. The proposed nanoprobe could not only be employed as a high-performance magnetic resonance imaging (MRI) agent for tumor and renal imaging but can also provide a platform for integrating therapeutic strategies toward tumors. The universal strategy could also be easily extended to the fabrication of other nanoprobes for MR imaging in vivo using other bioactive proteins including ovalbumin and transferrin. This work will open a new way for the development of biomaterials in biomedicine applications.
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