医学
盒内非相干运动
疾病
放射科
磁共振成像
磁共振弥散成像
病理
作者
C. Eleana Zhang,Sau May Wong,Renske Uiterwijk,Julie Staals,Walter H. Backes,Erik Hoff,Tobien Schreuder,Cécile R. L. P. N. Jeukens,Jacobus F.A. Jansen,Robert J. van Oostenbrugge
出处
期刊:Stroke
[Ovid Technologies (Wolters Kluwer)]
日期:2017-03-01
卷期号:48 (3): 658-663
被引量:25
标识
DOI:10.1161/strokeaha.116.015084
摘要
Cerebral small vessel disease (SVD) is associated with cognitive impairment. This may be because of decreased microstructural integrity and microvascular perfusion, but data on these relationships are scarce. We determined the relationship between cognition and microvascular perfusion and microstructural integrity in SVD patients, using intravoxel incoherent motion imaging-a diffusion-weighted magnetic resonance imaging technique designed to determine microvascular perfusion and microstructural integrity simultaneously.Seventy-three patients with SVD and 39 controls underwent intravoxel incoherent motion imaging and neuropsychological assessment. Parenchymal diffusivity D (a surrogate measure of microstructural integrity) and perfusion-related measure fD* were calculated for the normal appearing white matter, white matter hyperintensities, and cortical gray matter. The associations between cognitive performance and D and fD* were determined.In SVD patients, multivariable analysis showed that lower fD* in the normal appearing white matter and cortical gray matter was associated with lower overall cognition (P=0.03 and P=0.002, respectively), lower executive function (P=0.04 and P=0.01, respectively), and lower information-processing speed (P=0.04 and P=0.01, respectively). D was not associated with cognitive function. In controls, no association was found between D, fD*, and cognition.In SVD patients, lower cognitive performance is associated with lower microvascular perfusion in the normal appearing white matter and cortical gray matter. Our results support recent findings that both cortical gray matter and normal appearing white matter perfusion may play a role in the pathophysiology of cognitive dysfunction in SVD.URL: http://www.trialregister.nl. Unique identifier: NTR3786.
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