Tumor Location and Pathological Features of Latent and Incidental Prostate Cancer in Contemporary Japanese Men

No AccessJournal of UrologyAdult Urology1 Aug 2020Tumor Location and Pathological Features of Latent and Incidental Prostate Cancer in Contemporary Japanese Men Hiroyuki Inaba, Takahiro Kimura, Hajime Onuma, Shun Sato, Masahito Kido, Toshihiro Yamamoto, Yumiko Fukuda, Hiroyuki Takahashi, and Shin Egawa Hiroyuki InabaHiroyuki Inaba Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Takahiro KimuraTakahiro Kimura *Correspondence: Department of Urology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan E-mail Address: [email protected] Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Hajime OnumaHajime Onuma Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Shun SatoShun Sato Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Masahito KidoMasahito Kido Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Toshihiro YamamotoToshihiro Yamamoto Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Yumiko FukudaYumiko Fukuda Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Hiroyuki TakahashiHiroyuki Takahashi Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , and Shin EgawaShin Egawa Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000804AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The incidence of prostate cancer is increasing in Asian countries. Studies using prostatectomy specimens have reported a racial difference in tumor location within the prostate, with a greater incidence of transition zone cancer in Asian men compared with Caucasian men. However, there may be potential biases in studies based on surgical specimens. We describe the pathological features of subclinical prostate cancer, such as latent cancer and incidental cancer, to elucidate tumor location of contemporary Japanese patients. We also compare the prevalence of latent and incidental prostate cancer to determine whether the incidence of prostate cancer is higher in patients with bladder cancer. Materials and Methods: Overall 182 men autopsied and 148 who underwent cystoprostatectomy for bladder cancer were included in the study. Each prostate gland was fixed and sliced in step sections. Histological evaluation was performed by a single genitourinary pathologist. The index tumor location was categorized into transition zone or peripheral zone. Results: Prostate cancer was found in 39.0% of the autopsy specimens and 31.6% of the cystoprostatectomy specimens. The prevalence and pathological characteristics were not significantly different between latent and incidental cancer. The prevalence of transition zone cancer was 39.0% (46 of 118). In elderly men peripheral zone cancer was more frequently diagnosed than transition zone cancer (p=0.049). The pathological characteristics of transition and peripheral zone cancers were similar except for the pT stage. Conclusions: Transition zone cancer was prevalent in contemporary Japanese men. The incidence of prostate cancer in men with bladder cancer might not be higher than that in healthy men. References 1. : Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394. Google Scholar 2. : Epidemiology of prostate cancer in Asian countries. Int J Urol 2018; 25: 524. 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Link, Google Scholar No direct or indirect commercial, personal, academic, political, religious or ethical incentive is associated with publishing this article. © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byChen Y, Wu X and Yan W (2020) Tumor Location and Pathological Features of Latent and Incidental Prostate Cancer in Contemporary Japanese Men. Letter.Journal of Urology, VOL. 205, NO. 6, (1841-1841), Online publication date: 1-Jun-2021.Smith J (2020) This Month in Adult UrologyJournal of Urology, VOL. 204, NO. 2, (203-204), Online publication date: 1-Aug-2020. Volume 204Issue 2August 2020Page: 267-272 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.Keywordspathologyprostatic neoplasmsincidental findingsJapanMetricsAuthor Information Hiroyuki Inaba Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Takahiro Kimura Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan *Correspondence: Department of Urology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan E-mail Address: [email protected] More articles by this author Hajime Onuma Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Shun Sato Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Masahito Kido Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Toshihiro Yamamoto Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Yumiko Fukuda Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Hiroyuki Takahashi Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Shin Egawa Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Expand All No direct or indirect commercial, personal, academic, political, religious or ethical incentive is associated with publishing this article. 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