光动力疗法
放射治疗
纳米颗粒
纳米材料
体内
癌症治疗
辐照
癌症治疗
纳米技术
癌症
材料科学
医学物理学
癌症研究
计算机科学
医学
化学
放射科
生物
内科学
物理
生物技术
核物理学
有机化学
作者
Daria Kirsanova,Zaira Gadzhimagomedova,Alexey Maksimov,А. В. Солдатов
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2021-04-01
卷期号:21 (6): 677-688
被引量:6
标识
DOI:10.2174/1389557520666201111161705
摘要
: According to statistics, cancer is the second leading cause of death in the world. Thus, it is important to solve this medical and social problem by developing new effective methods for cancer treatment. An alternative to more well-known approaches, such as radiotherapy and chemotherapy, is photodynamic therapy (PDT), which is limited to the shallow tissue penetration (< 1 cm) of visible light. Since the PDT process can be initiated in deep tissues by X-ray irradiation (X-ray induced PDT, or XPDT), it has a great potential to treat tumors in internal organs. The article discusses the principles of therapies. The main focus is on various nanoparticles used with or without photosensitizers, which allow the conversion of X-ray irradiation into UV-visible light. Much attention is given to the synthesis of nanoparticles and analysis of their characteristics, such as size and spectral features. The results of in vitro and in vivo experiments are also discussed.
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