医学
腺癌
内科学
肺癌
肿瘤科
比例危险模型
肺
癌症
作者
Jie Gu,Lu Chen,Jìng Guo,Lingli Chen,Yiwei Chu,Yuan Ji
摘要
Abstract Background A new classification of pulmonary adenocarcinoma has been recently proposed by the International Association for the Study of Lung Cancer, American Thoracic Society and European Respiratory Society (IASLC/ATS/ERS). This study was undertaken in an attempt to explore the clinical implication of this new classification in Chinese patients. Methods Two hundred ninety‐two lung adenocarcinomas were reclassified strictly according to the IASLC/ATS/ERS classification by two pathologists, independently. Kaplan–Meier and Cox regression analyses were used to analyze the correlation between the new classification and patients' prognosis. Results We confirmed three groups with different outcomes. Both AIS and MIA had 100% 5‐year disease‐free survival rate and 100% 5‐year overall survival rate. Lepidic, acinar, and papillary as well as variants of invasive adenocarcinoma had intermediate prognosis. Solid and micropapillary cases had poor prognosis (DFS: P < 0.001, OS: P = 0.002). After controlling the clinicopathological factors, the new classification was identified as an independent prognostic factor in patients' disease‐free survival and overall survival. Conclusions We have demonstrated a valuable prognostic role of the new classification in Chinese patients. This new classification is valuable of screening out patients with high risk of recurrence to receive postoperative adjuvant therapy. J. Surg. Oncol. 2013;107:474–480. © 2012 Wiley Periodicals, Inc.
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