Lycopene ameliorates islet function and down-regulates the TLR4/MyD88/NF-κB pathway in diabetic mice and Min6 cells

In diabetic islets, the infiltration of macrophages into the intra-islets triggers islet β cells dysfunction. Lycopene may preserve M1/M2 macrophage homeostasis to improve islet function via the TLR4/MyD88/NF-κB signaling pathway.