化学
卡宾
镍
碳纤维
组合化学
立体化学
有机化学
催化作用
复合数
复合材料
材料科学
作者
Hosam Choi,Joohee Choi,Kiyoun Lee
标识
DOI:10.1021/acs.orglett.2c03800
摘要
In this report, we present a highly efficient approach for the synthesis of β,γ-disubstituted γ-butyrolactone motifs. This newly developed strategy is based on the combination of a diastereoselective aldol and a nickel carbene-mediated γ-butyrolactonization and uses an effective intramolecular ring closure to rapidly access a range of functionalized chiral γ-butyrolactones. This single-step approach was applied to produce straightforward asymmetric syntheses of (-)-talaumidin methyl ether, (+)-veraguensin, and (+)-dubiusamine A and a formal synthesis of (+)-phaseolinic acid as one of the shortest syntheses disclosed to date.
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