人血清白蛋白
化学
检出限
牛血清白蛋白
荧光
色谱法
选择性
血清白蛋白
呋喃
组合化学
生物化学
有机化学
物理
量子力学
催化作用
作者
Anirban Bandyopadhyay,Rituparna Hazra,Durba Roy,Anupam Bhattacharya
标识
DOI:10.1002/asia.202301055
摘要
Human serum albumin (HSA) is an important biomarker that can be used for the early diagnosis of many diseases. In this work, a TICT probe bearing fused naphtho‐furan scaffold (NPNF) was developed and employed in the selective turn‐on sensing of HSA. The probe’s selectivity towards HSA was observed using steady‐state fluorescence experiments, with limit of quantitation in micromolar levels. NPNF also displayed its capability exclusively towards HSA over bovine serum albumin (BSA), which was studied/rationalized using anisotropy and time‐resolved studies. Molecular docking was used to shed light on the location of NPNF in the domain I of HSA. The practical application of the probe was also demonstrated by the detection of HSA in urine and the HSA‐assisted detection of cerium.
科研通智能强力驱动
Strongly Powered by AbleSci AI