肿瘤微环境
免疫系统
癌症研究
纳米载体
材料科学
自愈水凝胶
生物
纳米技术
免疫学
药物输送
高分子化学
作者
Lisheng Zhu,Jingyu Liu,Mengjun Qiu,Jiayuan Chen,Qing Liang,Gang Peng,Zhenwei Zou
出处
期刊:Biomaterials
[Elsevier]
日期:2022-09-01
卷期号:288: 121711-121711
被引量:9
标识
DOI:10.1016/j.biomaterials.2022.121711
摘要
The tumor immune microenvironment (TIME) is one of the significant hallmarks of cancer and has the important role of largely determining the malignancy level of tumors. As an approach to break through this bottleneck of tumor treatment methods, the TIME can be reprogrammed by certain nanomaterials. Here, we coated C-novyi-spores with melittin-RADA32 nanofiber hybrid peptide and loaded the immunomodulator metformin to obtain MRM-coated spores as a powerful antitumor nanodrug against glioblastoma (GBM), which is based on the activation of the TIME. MRM-coated spores exhibit extended-release profiles and an enhanced killing effect on GBM both in vitro and in vivo. Furthermore, MRM-coated spores can educate the innate and adaptive immune system by inducing sustainable CD8+ T cell responses, promoting M1 macrophage polarization, and regulating the expression of HIF1-α, PDL1, and CXCL9 in TIME. In intracranial applications, MRM-coated spores showed excellent biosafety and a strong therapeutic effect. In summary, peptide hydrogels provide a promising strategy in which advantages of different treatment methods can be incorporated to synthesize potent antitumor drugs with mild side effects from bacteria-mediated nanomaterials.
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