异恶唑
化学
吡啶
环加成
三唑
1,2,3-三唑
炔丙基
立体化学
1,3-偶极环加成
三氟甲基
药物化学
组合化学
有机化学
烷基
催化作用
作者
K. Raju,Chandra Shekhar A,G. Sathaiah,Ravi Kumar A,B. Narsaiah,Shanthan Rao P,R Srujana,Srigiridhar Kotamraju
出处
期刊:Letters in Organic Chemistry
[Bentham Science]
日期:2014-02-01
卷期号:11 (4): 293-302
标识
DOI:10.2174/1570178610666131118223356
摘要
A series of novel 2-((1-substituted-1H-1,2,3-triazol-4-yl/3-substitutedisoxazol-5-yl)methoxy) substituted pyridine, 1-((1-substituted-1H-1,2,3-triazol-4-yl/3-substitutedisoxazol-5-yl)methyl)substituted pyridin-2(1H)-one was prepared from 2-oxo-6-phenyl/methyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 3 via propargylation followed by 1,3- dipolar cycloaddition of the propargyl derivatives 4 and 5. These triazole/isoxazole tagged pyridine derivatives were evaluated for antitumor activity against breast cancer cell lines such as MDA-MB-231, MCF-7 etc. The results indicated that compounds 6e, 6f, 8e and 8f were found to be active on MDA-MB-231, while 6h and 8h were active on MCF-7. Keywords: Nicotinonitrile, propargylation, antitumor activity, 1, 2, 3-triazole, isoxazole.
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