无鞭毛体
细胞内
活性氧
利什曼原虫
墨西哥利什曼原虫
生物
槲皮素
程序性细胞死亡
作用机理
细胞生物学
生物化学
体外
细胞凋亡
寄生虫寄主
抗氧化剂
万维网
计算机科学
作者
Fernanda Fonseca-Silva,Job D. F. Inacio,Marilene M. Canto‐Cavalheiro,Elmo Eduardo Almeida-Amaral
摘要
The present study reports the mechanism of the antileishmanial activity of quercetin against the intracellular amastigote form of Leishmania amazonensis. Treatment with 1 reduced the infection index in L. amazonensis-infected macrophages in a dose-dependent manner, with an IC₅₀ value of 3.4 μM and a selectivity index of 16.8, and additionally increased ROS generation also in a dose-dependent manner. Quercetin has been described as a pro-oxidant that induces the production of reactive oxygen species, which can cause cell death. Taken together, these results suggest that ROS production plays a role in the mechanism of action of 1 in the control of intracellular amastigotes of L. amazonensis.
科研通智能强力驱动
Strongly Powered by AbleSci AI