From a choleretic to an immunomodulator: Historical review of ursodeoxycholic acid as a medicament

利胆的 医学 熊去氧胆酸 内科学 胃肠病学
作者
Isao Makino,Hirotoshi Tanaka
出处
期刊:Journal of Gastroenterology and Hepatology [Wiley]
卷期号:13 (6): 659-664 被引量:53
标识
DOI:10.1111/j.1440-1746.1998.tb00707.x
摘要

Journal of Gastroenterology and HepatologyVolume 13, Issue 6 p. 659-664 From a choleretic to an immunomodulator: Historical review of ursodeoxycholic acid as a medicament ISAO MAKINO, Corresponding Author ISAO MAKINO Second Department of Internal Medicine, Asahikawa Medical College, Nishikagura, Asahikawa, JapanSecond Department of Internal Medicine, Asahikawa Medical College, Nishikagura, Asahikawa 078, Japan.Search for more papers by this authorHIROTOSHI TANAKA, HIROTOSHI TANAKA Second Department of Internal Medicine, Asahikawa Medical College, Nishikagura, Asahikawa, JapanSearch for more papers by this author ISAO MAKINO, Corresponding Author ISAO MAKINO Second Department of Internal Medicine, Asahikawa Medical College, Nishikagura, Asahikawa, JapanSecond Department of Internal Medicine, Asahikawa Medical College, Nishikagura, Asahikawa 078, Japan.Search for more papers by this authorHIROTOSHI TANAKA, HIROTOSHI TANAKA Second Department of Internal Medicine, Asahikawa Medical College, Nishikagura, Asahikawa, JapanSearch for more papers by this author First published: 28 June 2008 https://doi.org/10.1111/j.1440-1746.1998.tb00707.xCitations: 44AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Hammarsten O. Untersuchungen uber die Gallen einiger Polarthiere. I. Uber die Galle des Eisbaren. I Abschnitt, Hoppe-Seyler's. Z. Physiol. Chem. 1901; 32: 435–66. 2 Hammarsten O. Untersuchungen uber die Gallen einiger Polarthiere. I. Uber die Galle des Eisbaren. II Abschnitt, Hoppe-Seyler's. Z. Physiol Chem. 1902; 36: 525–55. 3 Shoda M. Uber die Ursodeoxycholsaure aus Barengallen und ihre physiologische Wirkung. J. Biochem. 1927; 7: 505–17. 4 Iwasaki T. Uber the Konstitution der ursodesoxycholsaure. Z. Physiol. Chem. 1936; 244: 181–93. 5 Kanazawa T, Shimazaki A, Sato T et al. Studies on the synthesis of ursodeoxycholic acid. Jpn. J. Chem. 1955; 76: 297–301. 6 Danzinger RG, Hofmann AF, Schoenfield LJ, Thistle JL. Dissolution of cholesterol gallstones by chenodeoxycholic acid. N. Engl. J. Med. 1972; 286: 1–8. 7 Makino I, Shinozaki K, Yoshino K. Nakagawa S. Dissolution of cholesterol gallstones by ursodeoxycholic acid. Jpn J. Gastroenterol. 1975; 72: 690–702. 8 Nakagawa S, Makino I, Ishizaki K, Dohi I. Dissolution of cholesterol gallstones by ursodeoxycholic acid. Lancet 1977; 2: 367–9. 9 Sugata F, Shimizu M. Retrospective studies on gallstone disappearance. Jpn. J. Gastroenterol. 1974; 71: 75–80. 10 Bachrach W, Hofmann AF. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Dig. Dis. Sci. 1982; 27: 737–61. 11 Bachrach W, Hofmann AF. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Dig. Dis. Sci. 1982; 27: 833–56. 12 Schoenfield LJ, Lachin JM, The Steering committee, The National Cooperative Gallstone Study Group. Chenodiol (chenodeoxycholic acid) for dissolution of gallstones; the national cooperative gallstone study. A controlled trial of efficacy and safety. Ann. Intern. Med. 1981; 95: 257–82. 13 Igimi H, Carey MC. Cholesterol gallstone dissolution in bile; dissolution kinetics of crystalline (anhydrate and mono hydrate) cholesterol with chenodeoxycholate, ursodeoxycholate, and their glycine and taurine conjugates. J. Lipid Res. 1981; 22: 254–70. 14 Igimi H, Asakawa S, Watanabe D, Shimura H. Liquid crystal formation in ursodeoxycholate-rich human gallbladder bile. Gastroenterology Jpn. 1983; 18: 93–7. 15 Igimi H, Nishijima S, Shimura H. The developmental process from micelle to liquid chrystal in the ursodeoxycholate, phosphatidylcholine and cholesterol solution. J. Phar. Dyn. 1983; 6: 267–71. 16 Admirand WH, Small DM. The physicochemical basis of cholesterol gallstone formation in man. J. Clin. Invest. 1968; 47: 1043–52. 17 Carey M, Small DM. The physical chemistry of cholesterol by solubility in bile; relationship to gallstone formation and dissolution in man. J. Clin. Invest. 1978; 61: 998–1026. 18 Ichida F. The experience of ursodeoxycholic acid administration for patients with chronic hepatitis. Sindan-to-tiryou. 1961; 49: 388–92 (in Japanese). 19 Wakahara T, Yoshida H, Bandou T et al. Effect of urso-san on chronic liver diseases. Sindan-to-tiryou. 1975; 63: 1070–3 (in Japanese). 20 Yamanaka M, Ohtou M, Obata H et al. Effect of ursodeoxycholic acid on chronic hepatitis; a double blind trial. Sindan-to-tiryou. 1976; 64: 2150–7 (in Japanese). 21 Leuschner U, Leuschner M, Sieratzki J, Kurtz W, Hubner K. Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years follow up; a pilot study. Dig. Dis. Sci. 1985; 30: 642–9. 22 Podda M, Ghezzi C, Battezzati PM et al. Effect of different doses of ursodeoxycholic acid in chronic liver disease. Dig. Dis. Sci. 1989; 34: (Suppl): S59–5. 23 Ballentani S, Tabarroni G, Barchi T et al. Effect of ursodeoxycholic acid treatment on alanine aminotransferase and gamma-glutamyltranspeptidase serum levels in patients with hyper-transaminasemia. J. Hepatol. 1989; 8: 7–12. 24 Guslandi M. Treatment of chronic liver disease with ursodeoxycholic acid. J. Int. Med. Res. 1990; 18: 497–505. 25 Podda M, Ghezzi C, Battezzati PM, Crosignani A, Zuin M, Podda A. Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis. Gastroenterology 1990; 98: 1044–50. 26 Rolandi E, Franceschini R, Caraldi A, Cicchetti V, Carati L, Barreca T. Effects of ursodeoxycholic acid (UDCA) on serum liver damage indices in patients with chronic active hepatitis. A double-blind controlled study. Eur. J. Clin. Pharmacol. 1991; 40: 473–6. 27 De Caestecker JS Jazrawi RP, Petroni ML, Northfield TC. Ursodeoxycholic acid in chronic liver disease. Dig. Dis. Sci. 1991; 36: 1061–5. 28 Crosignani A, Battezzati PM, Setchell DR et al. Effect of ursodeoxycholic acid on serum liver enzyme and bile acid metabolism in chronic active hepatitis; a dose-response study. Hepatology 1991; 13: 339–44. 29 Dumont M, Eringer S, Uchman S. Hypercholeresis induced by ursodeoxycholic acid in the rat; possible role of bicarbonate transport. Gastroenterology 1980; 79: 82–9. 30 Kitani K, Kanai S. Biliary transport maximum of tauroursodeoxycholate is twice as high as that of taurocholate in the rat. Life Sci. 1981; 29: 269–75. 31 Kitani K, Kanai S. Tauroursodeoxycholate prevents taurocholate increased cholestasis. Life Sci. 1982; 90: 515–23. 32 Kitani K, Ohta M, Kanai S. Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the rat. Am. J. Physiol. 1985; 248: G407–17. 33 Tomoda T, Moriwaki H, Onishi H et al. Therapeutic effect of ursodeoxycholic acid on sulpyrine-induced intrahepatic cholestasis; a case report. Jpn. J. Gastroenterol. 1984; 81: 2821–5 (in Japanese). 34 Poupon RE, Cheretien Y, Popon R, Ballet F, Calmus Y, Darnis F. Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis? Lancet 1987; 1: 834–6. 35 Roda E, Mazzella G, Bazzoli F et al. Effect of ursodeoxy cholic acid administration on biliary lipid secretion in primary biliary cirrhosis. Dig. Dis. Sci. 1989; 34: S52–8. 36 Matuzaki Y. Tanaka N, Osuga T et al. Improvement of biliary enzyme levels and itching as a result of long-term administration of ursodeoxycholic acid in primary biliary cirrhosis. Am. J. Gastroenterol. 1990; 85: 15–23. 37 Fukui H, Yamao J, Yoshitani M, Masumura Y, Tsujii T. Ursodeoxycholic acid therapy for primary biliary cirrhosis. In: K Inoue, ed. Primary biliary cirrhosis: pathophysiology, treatment and prognosis. Tokyo : Herusu Publishing Company, 1994; 147–58. 38 Floreani A, Zappala F, Mazzetto M, Naccarato R, Plebani M, Chiramonte M. Different response to ursodeoxycholic acid (UDCA) in primary biliary cirrhosis according to severity of diseases. Dis. Dis. Sci. 1994; 39: 9–14. 39 Poupon RE, Balkau B, Eschwege E, Poupon R, The UDCA-PBC Study Group: A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. N. Engl. J. Med. 1991; 324: 1548–54. 40 Oda H, Toda G, Ikeda Y et al. A multi-center double blind controlled trial of ursodeoxycholic acid for primary biliary cirrhosis. Gastroenterol Jpn. 1990; 25: 774–80. 41 Poupon RE, Poupon R, Balkau B, The UDCA-PBC Study Group. Ursodiol for the long-term treatment of primary biliary cirrhosis. N. Engl. J. Med. 1994; 330: 1342–7. 42 Lindor KD, Dickson ER, Baldus WP et al. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology 1994; 106: 1284–90. 43 Heathcote EJ, Cauch-Dudek K, Walker V et al. The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1994; 19: 1149–56. 44 Lindor KD, Dickson ER, Jorgensen RA et al. The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis; the results of a pilot study. Hepatology 1995; 22: 1158–62. 45 Ikeda T, Tozuka S, Noguchi O et al. Effects of additional administration of colchicine in ursodeoxycholic acidtreated patients with primary biliary cirrhosis: a prospective randomized study. J. Hepatol. 1996; 24: 88–94. 46 Tanaka S, Ito Y, Yokosaka O et al. A multicenter randomized controlled dose study of ursodeoxycholic acid for chronic hepatitis C. Hepatology 1994; 20: 558–64. 47 Kiso S, Kawata S, Imai Y, Tamura S, Inui Y, Ito N. Efficacy of ursodeoxycholic acid therapy in chronic viral hepatitis C with high serum gamma-glutamyltranspeptidase levels. J. Gastroenterol. 1996; 30: 75–80. 48 Boucher E, Jouanolle H, Andre P et al. Interferon and ursodeoxycholic acid combination therapy in the treatment of chronic viral C hepatitis: Results from a controlled randomized trial in 80 patients. Hepatology 1995; 21: 322–7. 49 Angelico M, Gandin C, Pescarmona E et al. Recombinant interferon-alpha and ursodeoxycholic acid versus interferon-alpha alone treatment of chronic hepatitis C: A randomized clinical trial with long-term follow-up. Am. J. Gastroenterol. 1995; 90: 263–9. 50 Tanaka K, Kondo M, Sakasguchi T et al. Efficacy of ursodeoxycholic acid in combination with interferon-α in treating chronic hepatitis C: Results of long-term follow-up trial. J. Gastroenterol. Hepatol 1996; 11: 1155–60. 51 Beuers U, Spengler U, Kruis W et al. Ursodeoxycholic acid for treatment of primary sclerosing cholangitis; placebocontrolled trial. Hepatology 1992; 16: 707–14. 52 Stiehl A, Walker S, Stieh L, Rudolph G, Hofmann WJ, Theilmann L. Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis, A 3-year pilot study with a placebo-controlled study period. J. Hepatol. 1994; 20: 57–64. 53 Mima S, Sekiya T, Kanagawa H et al. Effect of ursodeoxycholic acid on autoimmune hepatitis. Acta Hepatologica Japonica 1992; 34: 849–50. 54 Nakamura K, Akiyama K, Makino I. Effect of long term ursodeoxycholic acid treatment on serum liver enzyme and serum bile acid metabolism in chronic hepatitis. Jpn. J. Gastroenterol. 1995; 92: 62–71. 55 Toda G, Zeniya M, Watanabe F et al. Present status of autoimmune hepatitis in Japan—correlating the characteristics with international criteria in an area with a high rate of HCV infection. J. Hepatol 1997; 26: 1207–12. 56 Tsujii T, Yoshikawa M. Immunomodulation by bile acids. In: I Makino, ed. Bile acid and digestive disease: recent advance. Tokyo : Herusu Publishing Company. 1995; 11–14. 57 Gianni L, Di Padova F, Zuin M, Podda M. Bile acid induced lymphoproliferative response to phytohaemagglutinin and pokeweed mitogen; an in vitro study. Gastroenterology 1980; 78: 231–5. 58 Keane RM, Gudacz TR, Munster AM, Birmingham W, Winchurch RA. Impairment of human lymphocyte function by bile salts. Surgery 1984; 95: 439–43. 59 Lacaille F, Paradis K. The immunosuppressive effect of ursodeoxycholic acid: a comparative in vitro study on human peripheral blood mononuclear cells. Hepatology 1993; 18: 165–72. 60 Yoshikawa M, Tsujii T, Matsumura K et al. Immunomodulatory effects of ursodeoxycholic acid on immune responses. Hepatology 1992; 16: 358–64. 61 Terasaki S, Nakamura Y, Ogino H, Unoura M, Kabayashi K. Hepatocellular and biliary expression of HLA antigens in primary biliary cirrhosis before and after ursodeoxycholic acid therapy. Am. J. Gastroenterol. 1991; 86: 1194–9. 62 Calmus Y, Gane P, Rouger P, Poupon R, Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 199; 11: 12–15. 63 Hirano F, Tanaka H, Makino I. Regulation of the major histocompatibility complex class I mRNA expression by bile acids in cultured human hepatoma cells. Biochem. Biophys Res. Commun. 1993; 195: 1408–14. 64 Hirano F, Tanaka H, Makino Y et al. Effects of ursodeoxycholic acid and chenodeoxycholic acid on major histocompatibility complex class I gene expression. J. Gastroenterol. 1996; 31: 55–60. 65 Tanaka H, Makino Y, Miura T et al. Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. J. Immunol. 1996; 156: 1601–8. 66 Tanaka H, Makino I. Ursodeoxycholic acid-dependent activation of the glucocorticoid receptor. Biochem. Biophys. Res. Commun. 1992; 188: 942–8. 67 Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889–95. 68 Beato M. Gene regulation by steroid hormones. Cell 1989; 56: 335–44. 69 Tanaka H, Makino I. Bile acids and immune regulation. Jpn. J. Gastroenterol. 1996; 93: 693–9. Citing Literature Volume13, Issue6June 1998Pages 659-664 ReferencesRelatedInformation
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
顶顶顶发布了新的文献求助10
7秒前
mitu完成签到 ,获得积分10
8秒前
听说名字取得长的话就会被人记住完成签到,获得积分10
8秒前
10秒前
14秒前
14秒前
2799发布了新的文献求助10
18秒前
Owen应助微微采纳,获得10
20秒前
21秒前
Rita应助科研通管家采纳,获得10
23秒前
Orange应助科研通管家采纳,获得10
23秒前
科研八戒应助科研通管家采纳,获得10
23秒前
Rita应助科研通管家采纳,获得10
23秒前
23秒前
英姑应助科研通管家采纳,获得10
23秒前
23秒前
完美世界应助科研通管家采纳,获得10
23秒前
28秒前
Westfalen完成签到 ,获得积分10
30秒前
微微发布了新的文献求助10
33秒前
YINZHE应助蒋能能采纳,获得10
38秒前
大喵完成签到,获得积分20
40秒前
43秒前
优秀不愁发布了新的文献求助10
47秒前
zsx发布了新的文献求助10
52秒前
延陵君完成签到,获得积分10
53秒前
乔乔牌绅士完成签到,获得积分20
55秒前
56秒前
泡泡鱼完成签到 ,获得积分10
58秒前
雾散完成签到,获得积分10
1分钟前
天天快乐应助木木采纳,获得10
1分钟前
微微完成签到,获得积分20
1分钟前
1分钟前
1分钟前
zsx完成签到,获得积分10
1分钟前
1分钟前
个性的紫菜应助cqnuly采纳,获得10
1分钟前
1分钟前
拓跋老九完成签到,获得积分10
1分钟前
1分钟前
高分求助中
请在求助之前详细阅读求助说明!!!! 20000
One Man Talking: Selected Essays of Shao Xunmei, 1929–1939 1000
The Three Stars Each: The Astrolabes and Related Texts 900
Yuwu Song, Biographical Dictionary of the People's Republic of China 700
[Lambert-Eaton syndrome without calcium channel autoantibodies] 520
Bernd Ziesemer - Maos deutscher Topagent: Wie China die Bundesrepublik eroberte 500
A radiographic standard of reference for the growing knee 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2471307
求助须知:如何正确求助?哪些是违规求助? 2137984
关于积分的说明 5447963
捐赠科研通 1861927
什么是DOI,文献DOI怎么找? 925987
版权声明 562747
科研通“疑难数据库(出版商)”最低求助积分说明 495302