氯霉素
抗菌剂
医学
再生障碍性贫血
红霉素
抗生素
骨髓
免疫学
微生物学
生物
作者
Besen Sanga,Madan K. Kharel
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2024-01-01
卷期号:: 825-830
被引量:2
标识
DOI:10.1016/b978-0-12-824315-2.00349-3
摘要
Chloramphenicol is a broad-spectrum antimicrobial agent. It acts by inhibiting protein synthesis. Its high lipid solubility results in rapid absorption, a large volume of distribution, and accelerated penetration into almost all tissues. Aplastic anemia and bone marrow suppression are chloramphenicol's most serious adverse effects in humans. Circulatory system collapse, also known as “gray baby syndrome” in newborn infants, is associated with high serum levels of chloramphenicol. Chloramphenicol is also associated with the development of optic neuritis, scotoma with failing vision, and cleft lip. Chloramphenicol is classified as FDA pregnancy category C and requires caution if used during gestation and lactation.
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