The Blood Urea Nitrogen to Creatinine Ratio in Chronic Heart Failure: ‘ When the Past is Prologue ’

European Journal of Heart FailureVolume 26, Issue 2 p. 257-259 Invited Editorial The blood urea nitrogen to creatinine ratio in chronic heart failure: 'When the past is prologue' Rafael de la Espriella, Rafael de la Espriella Cardiology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain Centro de Investigación Biomédica en Red – Cardiovascular (CIBER-CV), Madrid, SpainSearch for more papers by this authorAlberto Ortiz, Alberto Ortiz Nephrology and Hypertension Department, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain RICORS2040 (Red de Investigación Renal), Instituto de Salud Carlos III, Sevilla, SpainSearch for more papers by this authorJulio Núñez, Corresponding Author Julio Núñez [email protected] [email protected] Cardiology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain Centro de Investigación Biomédica en Red – Cardiovascular (CIBER-CV), Madrid, Spain Department of Medicine, University of Valencia, Valencia, Spain Corresponding author. Cardiology Department, Hospital Clínico Universitario de Valencia, INCLIVA, Universitat de València, Avenida Blasco Ibanez 17, 46010 Valencia, Spain. Tel: +34 961 973500, Fax: +34 961 973979, Email: [email protected]; [email protected]Search for more papers by this author Rafael de la Espriella, Rafael de la Espriella Cardiology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain Centro de Investigación Biomédica en Red – Cardiovascular (CIBER-CV), Madrid, SpainSearch for more papers by this authorAlberto Ortiz, Alberto Ortiz Nephrology and Hypertension Department, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain RICORS2040 (Red de Investigación Renal), Instituto de Salud Carlos III, Sevilla, SpainSearch for more papers by this authorJulio Núñez, Corresponding Author Julio Núñez [email protected] [email protected] Cardiology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain Centro de Investigación Biomédica en Red – Cardiovascular (CIBER-CV), Madrid, Spain Department of Medicine, University of Valencia, Valencia, Spain Corresponding author. Cardiology Department, Hospital Clínico Universitario de Valencia, INCLIVA, Universitat de València, Avenida Blasco Ibanez 17, 46010 Valencia, Spain. Tel: +34 961 973500, Fax: +34 961 973979, Email: [email protected]; [email protected]Search for more papers by this author First published: 18 January 2024 https://doi.org/10.1002/ejhf.3146 The opinions expressed in this article are not necessarily those of the Editors of the European Journal of Heart Failure or of the European Society of Cardiology. doi: 10.1002/ejhf.3114. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Shannon JA. Glomerular filtration and urea excretion in relation to urine flow in the dog. Am J Physiol 1936; 117: 206–225. https://doi.org/10.1152/ajplegacy.1936.117.2.206 10.1152/ajplegacy.1936.117.2.206 CASWeb of Science®Google Scholar 2Fenton RA, Knepper MA. Urea and renal function in the 21st century: Insights from knockout mice. J Am Soc Nephrol 2007; 18: 679–688. https://doi.org/10.1681/ASN.2006101108 10.1681/ASN.2006101108 CASPubMedWeb of Science®Google Scholar 3Kazory A. Emergence of blood urea nitrogen as a biomarker of neurohormonal activation in heart failure. Am J Cardiol 2010; 106: 694–700. https://doi.org/10.1016/j.amjcard.2010.04.024 10.1016/j.amjcard.2010.04.024 CASPubMedWeb of Science®Google Scholar 4Quiroga B, Ortiz A, Díez J. Selective glomerular hypofiltration syndrome. 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