Quantitative Investigation of Neuroprotective Role of ROR1 in a Cell Culture Model of Alzheimer’s Disease
神经保护
疾病
神经科学
医学
心理学
内科学
作者
Kaushik Chanda,Debashis Mukhopadhyay
出处
期刊:Methods in molecular biology日期:2024-01-01卷期号:: 267-276
标识
DOI:10.1007/978-1-0716-3662-6_19
摘要
Cytoskeletal and microtubule atrophy are major hallmarks of Alzheimer’s disease (AD). A method to investigate endogenous proteins that can interact/stabilize the cytoskeleton (under pathological cues) is rare. Here, we describe how receptor tyrosine kinase-like orphan receptor 1 (ROR1), a receptor tyrosine kinase (RTK), can act as a neuroprotective molecule by promoting neurite outgrowth, stabilizing cytoskeletal components, and altering the dynamics of actin assembly in a cell culture model of AD.