双金属片
化学
自然键轨道
金属
配体(生物化学)
结晶学
嘧啶
立体化学
催化作用
计算化学
密度泛函理论
有机化学
受体
生物化学
作者
Mila Abaeva,Christian Ieritano,W. Scott Hopkins,Derek J. Schipper
标识
DOI:10.1021/acs.inorgchem.3c03062
摘要
With bimetallic catalysts becoming increasingly important, the development of electronically and structurally diverse binucleating ligands is desired. This work describes the synthesis of unsymmetric ligand 2,7-di(pyridin-2-yl)imidazo[1,2-a]pyrimidine (dpip) that is achieved in four steps on a multigram scale in an overall 54% yield. The ability of dpip to act as a scaffold for the formation of bimetallic complexes is demonstrated with the one-step syntheses of the dicopper complex [Cu2(dpip)(μ–OH)(CF3COO)3] (4), the dipalladium complex [Pd2(dpip)(μ–OH)(CF3COO)2](CF3COO)·CF3COOH (5), and the dimeric dinickel complex [Ni4(dpip)2(μ-Cl)4Cl2MeOH6][2Cl] (6) in good yields (79–92%). All bimetallic complexes were characterized by spectroscopic methods and X-ray crystallography, which revealed metal–metal distances between 3.4821(9) and 4.106(2) Å. Additionally, quantum chemical calculations were conducted on complex 4 and an analogous 1,8-naphthyridine-based dicopper complex to investigate the differences between the imidazopyrimidine motif reported here and the widely used 1,8-naphthyridine motif. Natural bonding orbital (NBO) and Mayer bond order (MBO) analyses validated the ability of dpip to coordinate metals more strongly. Finally, NBO calculations quantified the differences in the binding energy between the two pockets of the unsymmetrical dpip ligand.
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