生物
癌症研究
干细胞
白血病
淋巴细胞白血病
免疫学
状态5
前体细胞
表型
细胞
基因
细胞生物学
遗传学
标识
DOI:10.1093/jleuko/qiad094
摘要
Abstract Leukemia stem cells are known to drive tumor progression, drug resistance, microenvironmental shift, and relapse, which would make them a perfect therapeutic target. However, their phenotypic and functional similarity to their normal counterparts leaves limited road maps for their selective elimination. Tremblay et al. recently unraveled the fundamental role of overactivated pSTAT5 as a functional marker of early T cell precursor acute lymphoblastic leukemia stem cells driving leukemic progression and highlighted its potential use as a therapeutic target to prevent fatal outcomes.
科研通智能强力驱动
Strongly Powered by AbleSci AI