血管生成
生物
血管内皮生长因子
卵泡期
血管内皮生长因子A
调节器
内科学
内分泌学
卵泡
细胞生物学
卵泡闭锁
生长因子
窦卵泡
癌症研究
受体
血管内皮生长因子受体
医学
遗传学
基因
作者
Adrian Guzmán,Cyndi G. Hernández‐Coronado,Carlos Gutièrrez Gutiérrez,Ana María Rosales‐Torres
摘要
The vascular endothelial growth factor-A (VEGFA) system is a complex set of proteins, with multiple isoforms and receptors, including both angiogenic (VEGFxxx, VEGFR2) and antiangiogenic members (VEGFxxxb, VEGFR1 and soluble forms of VEGFR). The members of the VEGF system affect the proliferation, survival, and migration of endothelial and nonendothelial cells and are involved in the regulation of follicular angiogenesis and development. The production of VEGF by secondary follicles stimulates preantral follicular development by directly affecting follicular cells and promoting the acquisition of the follicular vasculature and downstream antrum formation. Additionally, the pattern of expression of the components of the VEGF system may provide a proangiogenic milieu capable of triggering angiogenesis and stimulating follicular cells to promote antral follicle growth, whereas, during atresia, this milieu becomes antiangiogenic and blocks follicular development.
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