载脂蛋白E
痴呆
神经科学
阿尔茨海默病
心理学
神经影像学
脑老化
认知老化
疾病
大脑结构与功能
认知
医学
病理
作者
Justin M. Palmer,Matthew J. Huentelman,Lee Ryan
标识
DOI:10.1016/j.tins.2023.06.003
摘要
The apolipoprotein ε4 (APOE ε4) allele is most commonly associated with increased risk for late-onset Alzheimer’s disease (AD). However, recent longitudinal studies suggest that these risks are overestimated; most ε4 carriers will not develop dementia in their lifetime. In this article, we review new evidence regarding the impact of APOE ε4 on cognition among healthy older adults. We discuss emerging work from animal models suggesting that ε4 impacts brain structure and function in multiple ways that may lead to age-related cognitive impairment, independent from AD pathology. We discuss the importance of taking an individualized approach in future studies by incorporating biomarkers and neuroimaging methods that may better disentangle the phenotypic influences of APOE ε4 on the aging brain from prodromal AD pathology.
科研通智能强力驱动
Strongly Powered by AbleSci AI