钙调神经磷酸酶
西罗莫司
医学
依维莫司
他克莫司
免疫抑制
硫唑嘌呤
药理学
免疫抑制剂
PI3K/AKT/mTOR通路
心脏移植
霉酚酸
霉酚酸酯
心力衰竭
心脏病学
内科学
移植
疾病
信号转导
生物
生物化学
作者
Aly Elezaby,Ryan Dexheimer,Karim Sallam
标识
DOI:10.3389/fcvm.2022.981838
摘要
Immunosuppressive medications are widely used to treat patients with neoplasms, autoimmune conditions and solid organ transplants. Key drug classes, namely calcineurin inhibitors, mammalian target of rapamycin (mTOR) inhibitors, and purine synthesis inhibitors, have direct effects on the structure and function of the heart and vascular system. In the heart, immunosuppressive agents modulate cardiac hypertrophy, mitochondrial function, and arrhythmia risk, while in vasculature, they influence vessel remodeling, circulating lipids, and blood pressure. The aim of this review is to present the preclinical and clinical literature examining the cardiovascular effects of immunosuppressive agents, with a specific focus on cyclosporine, tacrolimus, sirolimus, everolimus, mycophenolate, and azathioprine.
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