PRC2
合子
EZH2型
原核
YY1年
细胞生物学
化学
胚胎
生物
染色质
遗传学
胚胎发生
基因
基因表达
发起人
作者
Weijie Hao,Chenyang Huang,Defu Liu,Hongyu Xu,Yingxiang Liu,Yian Guan,Bingxue Chen,Zekun Guo
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2023-07-01
卷期号:325 (1): C286-C299
标识
DOI:10.1152/ajpcell.00041.2023
摘要
PGC7 and YY1 interaction inhibits recruitment of PRC2 by YY1. PGC7 promotes AKT and EZH2 interaction to increase pEZH2-S21 level, which weakens YY1 and EZH2 interaction, thereby decreasing H3K27me3 level. In zygotes, the PGC7-deficient and AKT inhibitor MK2206 promote EZH2 to enter the pronuclei, and increase H3K27me3 level in the pronuclei, as well as inhibition of the expression of zygote-activating genes regulated by H3K27me3 in two-cell embryos, which ultimately affects early embryo development.
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