自噬
银屑病
特应性皮炎
炎症
医学
角质形成细胞
免疫学
皮肤病科
生物
细胞凋亡
生物化学
体外
作者
Stephan Hailfinger,Klaus Schulze‐Osthoff
标识
DOI:10.1016/j.jid.2021.06.006
摘要
Dysfunctional autophagy is linked to various diseases, including psoriasis and atopic dermatitis. Recent evidence suggests that exposure of keratinocytes to TNF-α results in impaired autophagy and lysosomal function. The skin of patients with psoriasis and atopic dermatitis reveals a decreased expression of lysosomal cathepsins. Impaired autophagy is presumably involved in inflammation and disturbed keratinocyte differentiation, whereas stimulating autophagy might be a treatment option in inflammatory skin disease.
科研通智能强力驱动
Strongly Powered by AbleSci AI