生物医学中的光声成像
分子内力
光化学
纳米颗粒
聚合物
化学
光电子学
材料科学
光热治疗
吸收(声学)
纳米技术
光学
有机化学
物理
复合材料
作者
Menglei Zha,Xiangwei Lin,Jen‐Shyang Ni,Yaxi Li,Yachao Zhang,Xun Zhang,Lidai Wang,Kai Li
标识
DOI:10.1002/anie.202010228
摘要
Abstract Photoacoustic agents have been of vital importance for improving the imaging contrast and reliability against self‐interference from endogenous substances. Herein, we synthesized a series of thiadiazoloquinoxaline (TQ)‐based semiconducting polymers (SPs) with a broad absorption covering from NIR‐I to NIR‐II regions. Among them, the excited s‐BDT‐TQE, a repeating unit of SPs, shows a large dihedral angle and narrow adiabatic energy as well as low radiative decay, attributing to its strongly electron‐deficient ester‐substituted TQ‐segment. In addition, its more vigorous molecular motions trigger a higher reorganization energy that further yields an efficient photoinduced nonradiative decay, which has been carefully examined and understood by theoretical calculation. Thus, BDT‐TQE SP‐cored nanoparticles with twisted intramolecular charge transfer (TICT) feature exhibit a high NIR‐II photothermal conversion efficiency (61.6 %) and preferable PA tracking of in situ hepatic tumor growth for more than 20 days. This study highlights a unique strategy for constructing efficient NIR‐II photoacoustic agents via TICT‐enhanced PNRD effect, advancing their applications for in vivo bioimaging.
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