材料科学
生物传感器
等离子体子
表面等离子共振
光纤布拉格光栅
分析物
检出限
光电子学
纳米技术
分析化学(期刊)
波长
化学
纳米颗粒
色谱法
作者
Cátia Leitão,S. Pereira,Nélia Alberto,Maxime Lobry,Médéric Loyez,F.M. Costa,João Pinto,Christophe Caucheteur,Carlos Marques
出处
期刊:IEEE Sensors Journal
[Institute of Electrical and Electronics Engineers]
日期:2020-01-01
卷期号:: 1-1
被引量:72
标识
DOI:10.1109/jsen.2020.3025456
摘要
Cortisol is a stress biomarker whose chronic elevated levels are associated with higher risk of metabolic syndromes, anxiety, and cardiovascular diseases, among other medical conditions. A new immunosensor based on plasmonic tilted fiber Bragg grating (TFBG) has been developed and tested for rapid and ultrasensitive cortisol detection. The gold coated TFBG was characterized to surrounding refractive index (SRI) changes and functionalized with anti-cortisol antibodies via cysteamine. The functionalization was monitored, allowing to verify the SRI alteration at the fiber surface by the respective molecular adhesion. In this work, an alternative method to the monitoring of the most sensitive surface plasmon resonance mode was explored, based on tracking the local maximum of the plasmonic signature of the lower envelope of the spectra. With this interrogation method, the sensor achieved a sensitivity to cortisol detection of 0.275 ± 0.028 nm/ng.mL -1 , for the detection range of 0.1-10 ng/mL, with a total wavelength shift of around 3 nm, which is higher several orders of magnitude than the usually reported TFBG plasmonic immunosensors. The proposed biosensor provides a rapid, highly sensitive, label-free, low-volume consumption method for cortisol detection, with a working range suitable to monitor different biological samples.
科研通智能强力驱动
Strongly Powered by AbleSci AI