氧化应激
神经酰胺
鞘糖脂
内科学
内分泌学
氧化磷酸化
葡萄糖脑苷酶
生物化学
鞘脂
化学
酶
生物
医学
细胞凋亡
作者
Μαρινα Μωραιτου,Georgia Dermentzaki,Evangelia Dimitriou,Ioannis Monopolis,Natashe Lemos Dekker,Johannes M. F. G. Aerts,Leonidas Stefanis,Helen Michelakakis
标识
DOI:10.1016/j.neulet.2015.12.013
摘要
Several observations suggest that disturbed homeostasis of α-Synuclein (α-Syn) may provide a link between Gaucher disease (GD) and Parkinson’s disease (PD). We recently reported increased dimerization of α-Syn in the red blood cell (RBC) membrane of patients with GD. Several studies indicate a crucial relationship between lipids, oxidative stress and α-Syn status. Here we investigated the relationship between the observed increased dimerization of α-Syn in the cell membranes of RBCs, cells devoid of lysosomes and lacking lysosomal enzyme synthesis, and the lipid abnormalities and oxidative stress already described in GD. Correlation studies showed that in GD the α-Syn dimer/monomer ratio is positively correlated with the levels of glucosylceramide (GlcCer) and the glucosylceramide/ceramide (GlcCer/Cer) ratio and negatively with the levels of malonyldialdehyde (MDA) and plasmalogens. In conclusion, we have shown that the increased tendency of α-Syn to form dimers in the RBC membrane of patients with GD, is correlated with both the level of lipids, including GlcCer, the primary lipid abnormality in GD, and the increased oxidative stress observed in this disorder. The study of other tissues, and in particular brain, will be important in order to elucidate the significance of these findings regarding the link between GD and PD.
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