间变性淋巴瘤激酶
间皮瘤
医学
病理
表皮生长因子受体
癌症研究
免疫组织化学
染色体易位
荧光原位杂交
间变性大细胞淋巴瘤
淋巴瘤
生物
癌症
内科学
肺癌
生物化学
基因
恶性胸腔积液
染色体
作者
Kongsak Loharamtaweethong,Napaporn Puripat,Nadda Aoonjai,Apisada Sutepvarnon,Chanyoot Bandidwattanawong
摘要
Aims To report a case of paediatric malignant peritoneal mesothelioma ( MPM ) with evidence of anaplastic lymphoma kinase ( ALK ) translocation. Methods and results We describe a 10‐year‐old girl who presented with abdominal pain and progressive abdominal distension. She had no history of asbestos exposure. Histopathological, immunohistochemical and ultrastructural analyses were performed and showed a biphasic malignant mesothelioma. In addition, we also studied on a selected set of immunomarkers which may be the potential therapeutic molecular targets including ALK , c‐kit ( CD 117), epidermal growth factor receptor ( EGFR ) and human epidermal growth factor 2 ( HER 2)/ neu , as well as corresponding molecular analysis. Consequently, we identified ALK expression by immunohistochemistry, together with evidence of ALK translocation by fluorescent in‐situ hybridization ( FISH ) analysis. Conclusions Paediatric MPM is associated with ALK translocation in our case. The results may open up a new avenue for the study of molecular genesis of paediatric malignant mesothelioma in the future and help to determine whether patients MM s with ALK translocation would benefit from ALK inhibitor treatment.
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