细胞生物学
吞噬作用
巨噬细胞
吞噬细胞
细胞凋亡
传出细胞增多
川地31
化学
单核吞噬细胞系统
生物
细胞
免疫学
体外
生物化学
作者
Simon Brown,Isabelle Heinisch,Ewan A. Ross,Kenneth F. Shaw,Christopher D. Buckley,John Savill
出处
期刊:Nature
[Springer Nature]
日期:2002-07-01
卷期号:418 (6894): 200-203
被引量:352
摘要
Macrophage recognition and ingestion of 'self' cells undergoing apoptosis in vivo protects tissues from the toxic contents of dying cells and modulates macrophage regulation of inflammatory and immune responses. However, the complex molecular mechanisms mediating macrophage discrimination between viable and apoptotic cells are poorly understood. In particular, little is known of why viable nucleated cells are not engulfed by macrophages. To reveal active repulsion of viable cells and to seek specific capture or 'tethering' of apoptotic cells, we studied macrophage binding of viable and apoptotic leukocytes under conditions of flow. We found that homophilic ligation of CD31 (ref. 4) on viable leukocytes promoted their active, temperature-dependent detachment under low shear, whereas such CD31-mediated detachment was disabled in apoptotic leukocytes, promoting tight binding and macrophage ingestion of dying cells. Here we propose that CD31 (also known as platelet-endothelial cell adhesion molecule-1, PECAM-1) is an example of a cell-surface molecule that prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and which changes function on apoptosis, promoting tethering of dying cells to phagocytes.
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