抗体调理
补体系统
生物分子
抗体
化学
经典补体途径
生物物理学
纳米技术
材料科学
免疫学
生物化学
生物
调理素
作者
Vivian Vu,Geoffrey Gifford,Fangfang Chen,Halli Benasutti,Guankui Wang,Ernest Groman,Robert I. Scheinman,Laura Saba,S. Moein Moghimi,Dmitri Simberg
标识
DOI:10.1038/s41565-018-0344-3
摘要
Deposition of complement factors (opsonization) on nanoparticles may promote clearance from the blood by macrophages and trigger proinflammatory responses, but the mechanisms regulating the efficiency of complement activation are poorly understood. We previously demonstrated that opsonization of superparamagnetic iron oxide (SPIO) nanoworms with the third complement protein (C3) was dependent on the biomolecule corona of the nanoparticles. Here we show that natural antibodies play a critical role in C3 opsonization of SPIO nanoworms and a range of clinically approved nanopharmaceuticals. The dependency of C3 opsonization on immunoglobulin binding is almost universal and is observed regardless of the complement activation pathway. Only a few surface-bound immunoglobulin molecules are needed to trigger complement activation and opsonization. Although the total amount of plasma proteins adsorbed on nanoparticles does not determine C3 deposition efficiency, the biomolecule corona per se enhances immunoglobulin binding to all nanoparticle types. We therefore show that natural antibodies represent a link between biomolecule corona and C3 opsonization, and may determine individual complement responses to nanomedicines.
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