血清学
诺卡迪亚
诺卡菌病
免疫学
生物
诺卡氏菌感染
疾病
麻风病
抗原
医学
抗体
病理
细菌
遗传学
作者
Jean Hubble,Thai M. Cao,Judith A. Kjelstrom,William C. Koller,Blaine L. Beaman
标识
DOI:10.1128/jcm.33.10.2768-2769.1995
摘要
To test the hypothesis that Nocardia spp. may be an etiologic factor in Parkinson's disease (PD), we used a serodiagnostic panel to determine if PD patients had antibodies specific for Nocardia spp. To validate the serological test panel, sera from healthy volunteers and from patients with culture-proven nocardiosis (n = 307) were compared in part 1 of the study. The sensitivity of the panel was 88% for detection of culture-proven nocardial infections, and specificity was 85% (excluding cross-reactive leprosy cases). In part 2, no difference in seropositivity was found when PD patients were compared with their age- and gender-matched controls (n = 140). We found a high exposure rate of humans to nocardial antigens, especially among men and older individuals. Our results offer no support to the hypothesis that Nocardia spp. are causative in PD; however, it is possible that serological testing may not be optimal for detection of nocardial central nervous system infection.
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