化学
四糖
糖基
糖基化
立体化学
糖蛋白
聚糖
片段(逻辑)
酿酒酵母
生物化学
多糖
酵母
计算机科学
程序设计语言
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2021-06-04
卷期号:32 (20): 2053-2058
摘要
Abstract A glycophosphatidylinositol tetrasaccharide fragment was synthesized to mimic the core features of primary model, that of Saccharomyces cerevisiae. The salient feature of this approach is centered on the quick access to various α-1,2- and α-1,6-mannosyl and α-1,4-glycosyl linkages by using simple glycosylation and protective-group techniques. 1D and 2D-J-resolved NMR spectroscopy was used to verify the α-configuration of the new linkages. The tetrasaccharides obtained in this work are useful for examining fungal cell-wall glycoprotein cross-linking by transglycosidase enzymes for antifungal drug development.
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