昼夜节律
黑腹果蝇
生物钟
生物
模式生物
果蝇属(亚属)
功能(生物学)
细菌昼夜节律
有机体
神经科学
振荡基因
分子钟
细胞生物学
时间生物学
进化生物学
视交叉上核
遗传学
基因
系统发育学
作者
Ravi Allada,Brian Y. Chung
出处
期刊:Annual Review of Physiology
[Annual Reviews]
日期:2010-03-17
卷期号:72 (1): 605-624
被引量:376
标识
DOI:10.1146/annurev-physiol-021909-135815
摘要
Circadian clocks organize behavior and physiology to adapt to daily environmental cycles. Genetic approaches in the fruit fly, Drosophila melanogaster, have revealed widely conserved molecular gears of these 24-h timers. Yet much less is known about how these cell-autonomous clocks confer temporal information to modulate cellular functions. Here we discuss our current knowledge of circadian clock function in Drosophila, providing an overview of the molecular underpinnings of circadian clocks. We then describe the neural network important for circadian rhythms of locomotor activity, including how these molecular clocks might influence neuronal function. Finally, we address a range of behaviors and physiological systems regulated by circadian clocks, including discussion of specific peripheral oscillators and key molecular effectors where they have been described. These studies reveal a remarkable complexity to circadian pathways in this “simple” model organism.
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