生物
转录因子
缺氧诱导因子
缺氧诱导因子1
选择性拼接
基因
发起人
缺氧(环境)
Gα亚单位
遗传学
激活剂(遗传学)
蛋白质亚单位
细胞生物学
抄写(语言学)
计算生物学
外显子
基因表达
化学
氧气
哲学
有机化学
语言学
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2016-02-15
卷期号:310 (4): C260-C269
被引量:177
标识
DOI:10.1152/ajpcell.00315.2015
摘要
The hypoxia-inducible factor (HIF) family has three distinct members in most vertebrates. All three HIFs consist of a unique and oxygen-labile α-subunit and a common and stable β-subunit. While HIF-1 and HIF-2 function as master regulators of the transcriptional response to hypoxia, much less is known about HIF-3. The HIF-3α gene gives rise to multiple HIF-3α variants due to the utilization of different promoters, different transcription initiation sites, and alternative splicing. These HIF-3α variants are expressed in different tissues, at different developmental stages, and are differentially regulated by hypoxia and other factors. Recent studies suggest that different HIF-3α variants have different and even opposite functions. There is strong evidence that full-length HIF-3α protein functions as an oxygen-regulated transcription activator and that it activates a unique transcriptional program in response to hypoxia. Many HIF-3α target genes have been identified. While some short HIF-3α variants act as dominant-negative regulators of HIF-1/2α actions, other HIF-3α variants can inhibit HIF-1/2α actions by competing for the common HIF-β. There are also a number of HIF-3α variants yet to be explored. Future studies of these naturally occurring HIF-3α variants will provide new and important insights into HIF biology and may lead to the development of new therapeutic strategies.
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