亚功能化
新功能化
生物
基因复制
基因剂量
遗传学
基因
串联外显子复制
基因组
功能分歧
计算生物学
基因组进化
基因表达
基因家族
作者
Xun Lan,Jonathan K. Pritchard
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-05-20
卷期号:352 (6288): 1009-1013
被引量:166
标识
DOI:10.1126/science.aad8411
摘要
Gene duplication is a fundamental process in genome evolution. However, most young duplicates are degraded by loss-of-function mutations, and the factors that allow some duplicate pairs to survive long-term remain controversial. One class of models to explain duplicate retention invokes sub- or neofunctionalization, whereas others focus on sharing of gene dosage. RNA-sequencing data from 46 human and 26 mouse tissues indicate that subfunctionalization of expression evolves slowly and is rare among duplicates that arose within the placental mammals, possibly because tandem duplicates are coregulated by shared genomic elements. Instead, consistent with the dosage-sharing hypothesis, most young duplicates are down-regulated to match expression levels of single-copy genes. Thus, dosage sharing of expression allows for the initial survival of mammalian duplicates, followed by slower functional adaptation enabling long-term preservation.
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